Introducing Timless, an exciting new product crafted to slow down molecular aging by helping to maintain balanced, youthful cells while regenerating old ones. Timless is designed for everyone, but shows the most results for those aged 35 and above. Embrace the power of rejuvenation and take a step towards a more youthful you, with Timless.
Benefits
Supports the bodies ability to regenerate at a cellular level
Feel more energy, sharper focus, deeper sleep
Cognitive support and Neuro-protection
Reduces inflammation and oxidative stress
Over-time better resilience against the signs of ageing
Why do we age?
The Information Theory of Aging
Modern research pins only 20% of ageing to genetics. The other 80% is contributed to epigenetics, which controls when genes are turned on and off
Aging is caused by the loss of epigenetic information (cellular "software") over time, not just DNA damage (genetic "hardware")
Epigenetic changes disrupt gene expression, leading to cellular dysfunction and aging
Role of Sirtuins (Longevity Genes)
Sirtuins are proteins that regulate cellular health by repairing DNA and maintaining epigenetic stability
They are activated by NAD+, a coenzyme that declines with age and lifestyle factors
NAD+ Decline & Mitochondrial Dysfunction
Reduced NAD+ levels impair energy production, DNA repair, and sirtuin activity
Mitochondria (cell powerhouse) becomes inefficient, leading to cellular damage
mTOR & Nutrient Sensing
The mTOR pathway (a growth regulator) accelerates aging when overactive (e.g. from excessive protein intake)
Inhibiting mTOR may extend lifespan
Scenescent Cells"Zombie Cells"
Senescent cells form over time as regular cells lose their genetic identity, also known as "zombie cells"
Zombie cells stop dividing but secrete harmful inflammatory signals, as chemicals, into the body
Clearing out zombie cells has shown promise in reversing aging related decline
Whats in it?
How does Timeless work?
Nicotinamide Riboside
Targets: NAD+ depletion, mitochondiral dysfunction, sirtuin activation
How it works?
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Boosts NAD+ levels: NAD+ is essential for sirtuins (SIRT1, SIRT3 and SIRT6) that repair DNA, regulate metabolism, and maintain epigenetic stability
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Improves mitochondrial function: More NAD+ means better energy production and fewer damaging free radicals
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Suppressing inflammation: NAD+ helps to reduce chronic inflammation linked to aging
Why Nicotinamide Riboside over other NAD+ Boosters?
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Full UK compliance for human dietary supplements
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Some studies show that it is more efficiently absorbed than NMN
- Directly converts to NAD+ without intermediate steps
- Can be taken directly into the cell by passing through the cell wall
Liposomal
Trans-Resveratrol
Targets: Sirtuin activation, oxidative stress, mTOR inhibition
How it works?
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Activates SIRT1: Mimics calorie restriction, promoting cellular repair and longevity
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Enhances Nicotinamide Riboside's effects: Resveratrol helps stabilise NAD+ and improves sirtuin efficiency
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Antioxidant & anti-inflammatory: Reduces oxidative damage linked to aging
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May inhibit mTOR: Limits overactive growth signaling that accelerates aging
Why Liposomal?
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Better absorption than standard resveratrol (which has a poor bioavailability)
Spermidine
Targets: Cellular autophagy, epigenetic regulation, scenescence
How it works?
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Triggers autophagy: Clears out damaged proteins and organelles, rejuvenating cells (like a cellular "detox")
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Reduces scenescent cells: Helps remove "zombie cells" that drive inflammation
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Stabilises epigenetics: May protect against age-related gene expression changes (i.e. prevent loss of epigenetic information)
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Cardioprotective: Linked to lower heart disease risk in studies
Why from Wheat Germ Extract?
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Spermadine from wheat germ extract is currently the only approved source in the UK
Academic References
Extensive research has gone into these molecules by the worlds leading longevity scientists over the past 30+ years. We encourage you to explore the scientific references and clinical trials listed below. Don't just take our word for it—discover the research that supports our claims and see the evidence for yourself
Scientific Texts & Clinical Trials
Imai, S. and Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), pp.464–471. doi:https://doi.org/10.1016/j.tcb.2014.04.002.
Yoshino, M., Yoshino, J., Kayser, B.D., Patti, G., Franczyk, M.P., Mills, K.F., Sindelar, M., Pietka, T., Patterson, B.W., Imai, S.-I. and Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, [online] 372(6547). doi:https://doi.org/10.1126/science.abe9985.
Martens, C.R., Denman, B.A., Mazzo, M.R., Armstrong, M.L., Reisdorph, N., McQueen, M.B., Chonchol, M. and Seals, D.R. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications, 9(1). doi:https://doi.org/10.1038/s41467-018-03421-7
Baur, J.A. and Sinclair, D.A. (2006). Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews. Drug Discovery, [online] 5(6), pp.493–506. doi:https://doi.org/10.1038/nrd2060.
Timmers, S., Konings, E., Bilet, L., Houtkooper, Riekelt H., van de Weijer, T., Goossens, Gijs H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Moonen-Kornips, E., Hesselink, Matthijs K.C., Kunz, I., Schrauwen-Hinderling, Vera B., Blaak, E.E., Auwerx, J. and Schrauwen, P. (2011). Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans. Cell Metabolism, 14(5), pp.612–622. doi:https://doi.org/10.1016/j.cmet.2011.10.002.
Smoliga, J.M., Baur, J.A. and Hausenblas, H.A. (2011). Resveratrol and health - A comprehensive review of human clinical trials. Molecular Nutrition & Food Research, [online] 55(8), pp.1129–1141. doi:https://doi.org/10.1002/mnfr.201100143.
Madeo, F., Eisenberg, T., Pietrocola, F. and Kroemer, G. (2018). Spermidine in health and disease. Science, 359(6374), p.eaan2788. doi:https://doi.org/10.1126/science.aan2788.
Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., Tong, M., Ruckenstuhl, C., Dammbrueck, C., Gross, A.S., Herbst, V., Magnes, C., Trausinger, G., Narath, S., Meinitzer, A. and Hu, Z. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, [online] 22(12), pp.1428–1438. doi:https://doi.org/10.1038/nm.4222.
Pietrocola, F., Lachkar, S., Enot, D.P., Niso-Santano, M., Bravo-San Pedro, J.M., Sica, V., Izzo, V., Maiuri, M.C., Madeo, F., Mariño, G. and Kroemer, G. (2014). Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death & Differentiation, 22(3), pp.509–516. doi:https://doi.org/10.1038/cdd.2014.215
Trammell, S.A.J., Schmidt, M.S., Weidemann, B.J., Redpath, P., Jaksch, F., Dellinger, R.W., Li, Z., Abel, E.D., Migaud, M.E. and Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, [online] 7(1). doi:https://doi.org/10.1038/ncomms12948.
Bhatt, J.K., Thomas, S. and Nanjan, M.J. (2012). Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutrition research (New York, N.Y.), [online] 32(7), pp.537–41. doi:https://doi.org/10.1016/j.nutres.2012.06.003.
Liu, K., Zhou, R., Wang, B. and Mi, M.-T. (2014). Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. The American Journal of Clinical Nutrition, 99(6), pp.1510–1519. doi:https://doi.org/10.3945/ajcn.113.082024.
Wirth, M., Benson, G., Schwarz, C., Köbe, T., Grittner, U., Schmitz, D., Sigrist, S.J., Bohlken, J., Stekovic, S., Madeo, F. and Flöel, A. (2018). The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex, 109, pp.181–188. doi:https://doi.org/10.1016/j.cortex.2018.09.014.
